Tadalafil works by inhibiting the PDE5 enzyme, leading to increased levels of cyclic guanosine monophosphate (cGMP). This results in relaxation of the smooth muscles in the penile region and improved blood flow, facilitating an erection when sexually stimulated.Megalis 20 mg is a medication used to treat erectile dysfunction (ED) in men. It contains tadalafil as its active ingredient, which is a phosphodiesterase type 5 (PDE5) inhibitor. Tadalafil works by increasing blood flow to the penis, facilitating an erection when sexually stimulated.

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